College student Tadayasu Sawaki has a unique ability. He can see and communicate with bacteria and other microorganisms. Hijinks ensue. Sawaki Souemon Tadayasu is a freshmen in Tokyo agriculture university. He has a unique ability that worth the value of a 1 million yen electron microscope: to see microorganism with naked eyes. Together with his childhood friend, Kei, he begins a new and carefree life as a student.

Tachibana Mei is a quiet and unassuming girl, who has had no boyfriend and couldn't even make friends in 16 years. One day she accidentally injures Kurosawa Yamato, the most popular boy in school, and for some reason Yamato takes interest in her. He one-sidedly declares her his friend and it is through this tentative relationship, that Mei ultimately begins to understand the values of friendship and starts to befriend other people.

A world, forever beyond your expectations. In a dark, cramped, underground world of endless tunnels and shafts, people wear protective suits and live out their modest yet happy lives. The princess of the underground community, Patema, goes out exploring as always, inspired by her curiosity of the unknown depths of the world. Her favorite spot is the “danger zone”, an area forbidden by the “rule” of the community. Despite being frequently chastised by her caretaker Jii, she cannot hold back her curiosity for the reason behind the rule, because no one would tell her what the “danger” was. When she approaches the hidden “secret”, the story begins.

Tamako knows just about everything there is to know about mochi, the traditional Japanese dessert treats. When she’s not attending her first year of high school, she even invents new flavors and varieties for Tama-ya, her family’s mochi shop. School and growing up, on the other hand, are some things that she’s still trying to find the right recipe for. But with the help of her best friends Kanna and Midori, two girls whose parents run businesses in the same shopping district, Tamako’s determined to make the best of things. It’s complicated though, especially when it comes to emotions and her relationship with her best boy friend Mochizo, whose family runs a rival mochi shop. And lately, Kanna’s been feeling a little odd about her feelings towards Tamako as well. And what’s with up with that strange bird fluttering around, the one that speaks fluent Japanese? It’s all very mysterious and overwhelming, but at least Tamako always has one thing she can count on: No matter if your day’s been good or bad, there’s certain to be something sugary and delicious waiting at the end of every adventure whenever you take a walk through Tamako Market!